Gunnar Hapke

Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines

A. Harstrick, Carsten Bokemeyer, Martin Scharnofkse et al. · Cancer Chemotherapy and Pharmacology · 1993 · 53 citations

Medicine, Medicinal Chemistry, Oncology +13

Induction of Biphasic DNA Double Strand Breaks and Activation of Multiple Repair Protein Complexes by DNA Topoisomerase I Drug 7-Ethyl-10-hydroxy-camptothecin

Jiaxi Wu, Ming-Biao Yin, Gunnar Hapke et al. · Molecular Pharmacology · 2002 · 48 citations

Medicine, Molecular Biology, Oncology +17

Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1α expression, resulting in reduced angiogenesis

M-B Yin, Z-R Li, Károly Tóth et al. · Oncogene · 2006 · 37 citations

Medicine, Oncology, Pharmacology +17

Chk1 signaling pathways that mediated G2M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350

Ming-Biao Yin, Gunnar Hapke, Jiaxi Wu et al. · Biochemical and Biophysical Research Communications · 2002 · 23 citations

Life Sciences, Molecular Biology, Oncology +16

Upfront FOLFOXIRI+bevacizumab followed by fluoropyrimidin and bevacizumab maintenance in patients with molecularly unselected metastatic colorectal cancer

Alexander Stein, Djordje Atanackovic, Bert Hildebrandt et al. · British Journal of Cancer · 2015 · 19 citations · Full text

Medicine, Oncology, Pharmacology +10