Mitsuharu Nakamura

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Tomohiro Yoshida, Fumihiko Akahoshi, Hiroshi Sakashita et al. · Bioorganic & Medicinal Chemistry · 2012 · 150 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Identification of a Potent and Orally Active Non-peptide C5a Receptor Antagonist

Hiroshi Sumichika, Kei Sakata, Noriko Sato et al. · Journal of Biological Chemistry · 2002 · 100 citations · Full text

Medicine, Immunology, Pharmacology +14

Synthesis and Synthetic Utilization of α-Functionalized Vinylphosphonates Bearing β-Oxy or β-Thio Substituents

Ryoji Kouno, Tatsuo Okauchi, Mitsuharu Nakamura et al. · The Journal of Organic Chemistry · 1998 · 64 citations

Natural Sciences, Chemistry, Green Chemistry +7

Removal of Sphingosine 1-Phosphate Receptor-3 (S1P₃) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P₁ Agonists with Reduced Effect on Heart Rate

Maiko Hamada, Mitsuharu Nakamura, Masatoshi Kiuchi et al. · Journal of Medicinal Chemistry · 2010 · 41 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11

Synthesis and Synthetic Application of Phosphonoketene Dithioacetals. New Synthesis of Dithioallenes and (α-Dithiocarboxyvinyl)phosphonates

Toru Minami, Tatsuo Okauchi, Hiroyasu Matsuki et al. · The Journal of Organic Chemistry · 1996 · 37 citations

Natural Sciences, Chemistry, Green Chemistry +7