Attenuated Cold Sensitivity in TRPM8 Null Mice

Raymond W. Colburn, Mary Lou Lubin, Dennis J. Stone, +6

Neuron

Knockout MouseMolecular PhysiologyPhysiologyAutoimmunityTolerance Induction +3

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

Na Qin, Michael P. Neeper, Yi Liu, +3

Journal of Neuroscience

Cannabinoid Receptor-NeurotransmissionCannabinoid PharmacologyChannel PropertiesMediates Cgrp Release +17

Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Daniel J. Parks, William H. Parsons, Raymond W. Colburn, +13

Journal of Medicinal Chemistry

Vivo AntagonismDrug TargetPain MedicineNeuropathic PainMolecular Pain +17

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

Raul R. Calvo, Sanath K. Meegalla, Daniel J. Parks, +7

Bioorganic & Medicinal Chemistry Letters

AllergyAntiparasitic AgentMedicineCold AllodyniaMechanism Of Action +7

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

Jay M. Matthews, Raymond W. Colburn, Scott L. Dax, +12

Bioorganic & Medicinal Chemistry Letters

MedicineMechanism Of ActionMolecular BiologyPharmacologyDrug Discovery

Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine

Yi Liu, Mary Lou Lubin, Tasha L. Reitz, +3

European Journal of Pharmacology

Signal TransductionMolecular PhysiologyG Protein-coupled ReceptorPhysiologyReceptor (Biochemistry) +8

Novel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Advancement of <i>N</i> -((Benzo[ <i>b</i> ]thien-3-yl)methyl)sulfamide (JNJ-26990990) into Human Clinical Studies

Michael H. Parker, Virginia L. Smith‐Swintosky, David F. McComsey, +15

Journal of Medicinal Chemistry

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

Bin Zhu, Mingde Xia, Xiaoqing Xu, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologySignal TransductionBiochemistryFunctional SelectivityMedicine +8

Benzo[<i>d</i>]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of <i>trans</i>-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1<i>H</i>-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

William H. Parsons, Raul R. Calvo, Wing S. Cheung, +14

Journal of Medicinal Chemistry

Novel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Pharmacological Properties of (<i>S</i>)-<i>N</i>-[(6-Chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)

David F. McComsey, Virginia L. Smith‐Swintosky, Michael H. Parker, +12

Journal of Medicinal Chemistry