Lawrence C. S. Tam

A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement

Sara J. Bowne, Marian M. Humphries, Lori S. Sullivan et al. · European Journal of Human Genetics · 2011 · 155 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma

Jeffrey O’Callaghan, Darragh E. Crosbie, Paul Cassidy et al. · Human Molecular Genetics · 2017 · 86 citations · Full text

Medicine, Ophthalmology, Ocular Disease +16

An experimental platform for systemic drug delivery to the retina

Matthew Campbell, Anh T. H. Nguyen, Anna‐Sophia Kiang et al. · Proceedings of the National Academy of Sciences · 2009 · 74 citations · Full text

Medicine, Ophthalmology, Pharmacology +17

Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)

Lawrence C. S. Tam, Anna‐Sophia Kiang, Avril Kennan et al. · Human Molecular Genetics · 2008 · 63 citations · Full text

Medicine, Molecular Biology, Ophthalmology +17

Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)

Lawrence C. S. Tam, Anna‐Sophia Kiang, Matthew Campbell et al. · Human Molecular Genetics · 2010 · 45 citations · Full text

Medicine, Genetics, Pharmacology +15