Nigel G. Cooke

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

Shifeng Pan, Nathanael S. Gray, Wenqi Gao et al. · ACS Medicinal Chemistry Letters · 2013 · 165 citations · Full text

Molecular Biology, Pharmaceutical Chemistry, Medicinal Chemistry +16

Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

Rainer Albert, Klaus Hinterding, Volker Brinkmann et al. · Journal of Medicinal Chemistry · 2005 · 150 citations · Full text

Bioorganic Chemistry, Biologically Active Species, Vivo Phosphorylation +18

The total synthesis of (+)-ionomycin

Stephen Hanessian, Nigel G. Cooke, Brad DeHoff et al. · Journal of the American Chemical Society · 1990 · 137 citations

Altmetrics, Medicinal Chemistry, Donut Icon +12

Discovery of 3-(1<i>H</i>-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

Jürgen Wagner, Peter Matt, Richard Sedrani et al. · Journal of Medicinal Chemistry · 2009 · 131 citations · Full text

A Monoselective Sphingosine-1-Phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model

Shifeng Pan, Yuan Mi, Charles Pally et al. · Chemistry & Biology · 2006 · 125 citations

Heart Failure, Transplantation, Xenotransplantation +7