Roger G. Spragg

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

Paul A. Hyslop, Daniel B. Hinshaw, W A Halsey et al. · Journal of Biological Chemistry · 1988 · 624 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Ingrid U. Schraufstätter, Daniel B. Hinshaw, Paul A. Hyslop et al. · Journal of Clinical Investigation · 1986 · 513 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Evidence of lung surfactant abnormality in respiratory failure. Study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol.

Mikko Hallman, Roger G. Spragg, James H. Harrell et al. · Journal of Clinical Investigation · 1982 · 466 citations · Full text

Medicine, Biochemistry, Internal Medicine +17

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

Ingrid U. Schraufstätter, Paul A. Hyslop, Daniel B. Hinshaw et al. · Proceedings of the National Academy of Sciences · 1986 · 462 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome

Roger G. Spragg, James F. Lewis, Hans‐Dieter Walmrath et al. · New England Journal of Medicine · 2004 · 419 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17