Alex N. F. Brown

New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo.

Philip E. Thorpe, Philip M. Wallace, Phillip P. Knowles et al. · PubMed · 1987 · 204 citations

Immunotoxicology, Disulfide Linkage, Improved Stability +20

An Immunotoxin Composed of Monoclonal Anti-Thy 1.1 Antibody and a Ribosome-Inactivating Protein From <italic>Saponaria officinalis:</italic> Potent Antitumor Effects In Vitro and In Vivo

Philip E. Thorpe, Alex N. F. Brown, J Bremner et al. · JNCI Journal of the National Cancer Institute · 1985 · 129 citations

Potent Antitumor Effects, Toxinology, Immunotoxicology +18

Modification of the carbohydrate in ricin with metaperiodate — cyanoborohydride mixtures

Philip E. Thorpe, Simone Detre, Brian M. J. Foxwell et al. · European Journal of Biochemistry · 1985 · 115 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +14

Blockade of the galactose‐binding sites of ricin by its linkage to antibody

Philip E. Thorpe, W. C. J. Ross, Alex N. F. Brown et al. · European Journal of Biochemistry · 1984 · 94 citations · Full text

Immunocytochemical Technique, Immunotoxicology, Glycobiology +18

Evaluation of four CD22 antibodies as ricin a chain‐containing immunotoxins for the <i>in vivo</i> therapy of human B‐cell leukemias and lymphomas

Guo‐Liang Shen, Jialing Li, Maria‐Ana Ghetie et al. · International Journal of Cancer · 1988 · 71 citations