PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Bradley A. Zinker, Cristina M. Rondinone, James M. Trevillyan, +19

Proceedings of the National Academy of Sciences

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice†

Xing Yu, Susan F. Murray, Sanjay K. Pandey, +8

Hepatology

Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice

Madeline Butler, Robert A. McKay, Ian Popoff, +6

Diabetes

Insulin SignalingOxidative StressMetabolic SyndromeSpecific InhibitionReceptor Tyrosine Kinase +18

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

Yoshio Nagai, Shin Yonemitsu, Derek M. Erion, +15

Cell Metabolism

Insulin ResistanceMetabolic SyndromeBiochemistryMedicinePhysiology +7

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

Derek M. Erion, Shin Yonemitsu, Yongzhan Nie, +14

Proceedings of the National Academy of Sciences

Sirt1 AsoImmunologyFatty Liver DiseaseInsulin SignalingOxidative Stress +20

Deficiency of Adiponectin Receptor 2 Reduces Diet-Induced Insulin Resistance but Promotes Type 2 Diabetes

Yanfang Liu, M. Dodson Michael, Shera Kash, +9

Endocrinology

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

Derek M. Erion, Irena D. Ignatova, Shin Yonemitsu, +17

Cell Metabolism

Metabolic SyndromeHepatologyBiochemistryLiver PhysiologyPhysiology +10

Brain natriuretic peptide is induced by alpha 1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes

Deanna S. Hanford, Donna J. Thuerauf, Susan F. Murray, +1

Journal of Biological Chemistry

Primary Response GeneCardiac MuscleHeart FailureNeuropeptidesAlpha 1-Adrenergic Agonists +20

The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats

Derek M. Erion, Violetta Popov, Jennifer J. Hsiao, +13

Endocrinology

NutritionGlycobiologyFatty Liver DiseaseExperimental NutritionInsulin Signaling +19

Myocardial alpha-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression.

C C Glembotski, C.E. Irons, Kevin A. Krown, +3

Journal of Biological Chemistry

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologySignal Transduction +13