Stanislav Drápela

Altered propionate metabolism contributes to tumour progression and aggressiveness

Ana P. Gomes, Didem Ilter, Vivien Low et al. · Nature Metabolism · 2022 · 101 citations · Full text

Tumor Biology, Metabolic Reprogramming, Medicine +6

Furo[3,2‐<i>b</i>]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

Václav Němec, Michaela Hylsová, Lukáš Maier et al. · Angewandte Chemie International Edition · 2018 · 55 citations

Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core

Václav Němec, Lukáš Maier, Benedict‐Tilman Berger et al. · European Journal of Medicinal Chemistry · 2021 · 29 citations · Full text

Medicinal Chemistry, Protein Kinases Clk, Biochemistry +8

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Didem Ilter, Stanislav Drápela, Tanya Schild et al. · Redox Biology · 2023 · 29 citations · Full text

Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

Pounami Samadder, Tereza Suchánková, Ondřej Hylse et al. · Molecular Cancer Therapeutics · 2017 · 24 citations