Thomas T. Nguyen

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 722 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor

Thomas T. Nguyen, Jean‐Claude Scimeca, Chantal Filloux et al. · Journal of Biological Chemistry · 1993 · 224 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics

Richard M. Keenan, William H. Miller, Linda S. Barton et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 30 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

Richard M. Keenan, William H. Miller, M. Amparo Lago et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 24 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model

Richard M. Keenan, M. Amparo Lago, William H. Miller et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 21 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8