Bruce C. Richardson

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

Jawaid Quddus, K J Johnson, Jerrie Gavalchin et al. · Journal of Clinical Investigation · 1993 · 360 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis

Anura Hewagama, Dipak Patel, Sri G. Yarlagadda et al. · Genes and Immunity · 2009 · 306 citations · Full text

Life Sciences, Bioinformatics, Immunology +14

Demethylation of the Same Promoter Sequence Increases CD70 Expression in Lupus T Cells and T Cells Treated with Lupus-Inducing Drugs

Qianjin Lu, Ailing Wu, Bruce C. Richardson · The Journal of Immunology · 2005 · 266 citations · Full text

Medicine, Genetics, Molecular Biology +14

Decreased ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients

Chun Deng, Mariana J. Kaplan, Donna Ray et al. · Arthritis & Rheumatism · 2001 · 253 citations · Full text

Life Sciences, Genetics, Immunology +15

Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity

Sanjay Rajagopalan, Emily C. Somers, Robert D. Brook et al. · Blood · 2004 · 250 citations

Life Sciences, Cell Biology, Immunology +17