Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, +23

EMBO Molecular Medicine

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate

Katsuji Aikawa, Moriteru Asano, Koji Ono, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPart IiiMedicineAnabolic SteroidsDerivative 2F +11

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

Jonathan B. Steinman, Cristina Santarossa, Rand M. Miller, +19

eLife

Combinatorial ChemistryUnique ModeMolecular BiologyCytoskeletonMotor Proteins +21

Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-<i>a</i>]pyrazine Scaffold as a Novel Proline Mimetic

Kentaro Hashimoto, Bunnai Saito, Naoki Miyamoto, +20

Journal of Medicinal Chemistry

Chemoprevention StrategyPotent InhibitorNovel Proline MimeticPharmacotherapyChemical Biology +17

Synthetic Studies toward GKK1032s, Novel Antibiotic Antitumor Agents:  Enantioselective Synthesis of the Fully Elaborated Tricyclic Core via an Intramolecular Diels−Alder Cycloaddition

Moriteru Asano, Munenori Inoue, Kazuhiro Watanabe, +2

The Journal of Organic Chemistry

Nickel-Catalyzed Coupling Producing (2<i>Z</i>)-2,4-Alkadien-1-ols, Conversion to (<i>E</i>)-3-Alkene-1,2,5-triol Derivatives, and Synthesis of Decarestrictine D

Yuichi Kobayashi, Shinya Yoshida, Moriteru Asano, +2

The Journal of Organic Chemistry

EngineeringOrganic ChemistryChemistryDecarestrictine DOrganometallic Catalysis +14

Stereoselective Synthesis of Decarestrictine D from a Previously Inaccessible (2<i>Z</i>,4<i>E</i>)-Alkadienyl Alcohol Precursor

Yuichi Kobayashi, Moriteru Asano, Shinya Yoshida, +1

Organic Letters

Inorganic ChemistryEngineeringCore StructureDecarestrictine DOrganic Chemistry +8

Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors

Ryo Mizojiri, Moriteru Asano, Daisuke Tomita, +9

Journal of Medicinal Chemistry

Medicinal ChemistrySelective Acc1 InhibitorMedicineRational Drug DesignCompound 1Q +9

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives

Moriteru Asano, Takenori Hitaka, Takashi Imada, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineAnabolic SteroidsNatural Sciences +8

Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists

Moriteru Asano, Kentaro Hashimoto, Bunnai Saito, +11

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryNovel Tri-cyclic CompoundsBiochemistryMedicineApoptosis Proteins +7