Liangzhong Lim

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

Liangzhong Lim, Yuanyuan Wei, Yimei Lu et al. · PLoS Biology · 2016 · 200 citations · Full text

Amyloid Oligomers, Protein Assembly, Molecular Biology +16

TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA

Haina Qin, Liangzhong Lim, Yuanyuan Wei et al. · Proceedings of the National Academy of Sciences · 2014 · 155 citations · Full text

A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

Jian Kang, Liangzhong Lim, Yimei Lu et al. · PLoS Biology · 2019 · 141 citations · Full text

Protein Assembly, Molecular Biology, Protein Phase Separation +19

ATP enhances at low concentrations but dissolves at high concentrations liquid-liquid phase separation (LLPS) of ALS/FTD-causing FUS

Jian Kang, Liangzhong Lim, Jianxing Song · Biochemical and Biophysical Research Communications · 2018 · 110 citations

Biochemistry, Natural Sciences, Membrane Transport +8

Dynamically-Driven Enhancement of the Catalytic Machinery of the SARS 3C-Like Protease by the S284-T285-I286/A Mutations on the Extra Domain

Liangzhong Lim, Jiahai Shi, Yuguang Mu et al. · PLoS ONE · 2014 · 96 citations · Full text

Crystal Structure, Protein Assembly, Biomolecular Structure Prediction +17