Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1)

Diana Bonderman, Ingrid Pretsch, Regina Steringer‐Mascherbauer, +10

CHEST Journal

Cinaciguat (BAY 58–2667) Improves Cardiopulmonary Hemodynamics in Patients With Acute Decompensated Heart Failure

Harald Lapp, Veselin Mitrović, Norbert Franz, +6

Circulation

Single‐Dose Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of the Soluble Guanylate Cyclase Stimulator BAY 63‐2521: An Ascending‐Dose Study in Healthy Male Volunteers

Reiner Frey, Wolfgang Mück, Sigrun Unger, +3

The Journal of Clinical Pharmacology

HypertensionHealthy SubjectsCardiovascular PharmacologyPulmonary HypertensionPharmacotherapy +16

Riociguat for pulmonary arterial hypertension associated with congenital heart disease

Stephan Rosenkranz, Hossein Ardeschir Ghofrani, Maurice Beghetti, +6

Heart

Stimulation of Soluble Guanylate Cyclase Prevents Cigarette Smoke–induced Pulmonary Hypertension and Emphysema

Borja Lobo, Alexandra Pichl, Nirmal Parajuli, +24

American Journal of Respiratory and Critical Care Medicine

Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of the Soluble Guanylate Cyclase Activator Cinaciguat (BAY 58‐2667) in Healthy Male Volunteers

Reiner Frey, Wolfgang Mück, Sigrun Unger, +3

The Journal of Clinical Pharmacology

HypertensionHeart FailureCardiovascular PharmacologyPharmacotherapyPharmacodynamic Modeling +15

Riociguat (BAY 63–2521) and Warfarin: A Pharmacodynamic and Pharmacokinetic Interaction Study

Reiner Frey, Wolfgang Mück, Nina Kirschbaum, +3

The Journal of Clinical Pharmacology

ThrombosisDrug InteractionsPharmacological StudyPharmacokinetic Interaction StudyMedicine +10

Acute Effects of Riociguat in Borderline or Manifest Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease

Hossein Ardeschir Ghofrani, Gerd Staehler, Ekkehard Grünig, +8

Pulmonary Circulation

HypertensionPharmacotherapyAcute EffectsPulmonary PharmacologyPublic Health +14

Left Ventricular Systolic Dysfunction Associated with Pulmonary Hypertension Riociguat Trial (LEPHT): Rationale and Design

Stefano Ghio, Diana Bonderman, Stephan B. Felix, +7

European Journal of Heart Failure

Assessment of the Effects of Renal Impairment and Smoking on the Pharmacokinetics of a Single Oral Dose of the Soluble Guanylate Cyclase Stimulator Riociguat (BAY 63‐2521)

Reiner Frey, Corina Becker, Sigrun Unger, +3

Pulmonary Circulation