Jacob John

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

Ute Krengel, Ilme Schlichting, Anna Scherer et al. · Cell · 1990 · 393 citations

Signal Switch Molecules, Molecular Regulation, Molecular Biology +7

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K <i>rev</i> -1 Gene Product

Matthias Frech, Jacob John, Véronique Pizon et al. · Science · 1990 · 256 citations

Molecular Regulation, Signal Recognition, Molecular Biology +17

Characterisation of the metal‐ion–GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the ¹⁷O‐Mn superhyperfine coupling and by kinetic methods

Jürgen Feuerstein, Hans Robert Kalbitzer, Jacob John et al. · European Journal of Biochemistry · 1987 · 71 citations

Viral Replication, Protein Assembly, Molecular Biology +17

Mutational and Kinetic Analyses of the GTPase-Activating Protein (GAP)-p21 Interaction: The C-Terminal Domain of GAP Is Not Sufficient for Full Activity

Petra Gideon, Jacob John, Matthias Frech et al. · Molecular and Cellular Biology · 1992 · 49 citations

Full Activity, Signal Transduction, Gtpase-activating Protein +14

Proton NMR studies of transforming and nontransforming H-ras p21 mutants

Ilme Schlichting, Jacob John, Mathias Frech et al. · Biochemistry · 1990 · 30 citations

Crystal Structure, Biochemistry, Biomolecular Structure Prediction +14