Matthias Frech

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

Jian-Ping Xiong, Thilo Stehle, Rongguang Zhang et al. · Science · 2002 · 1.6K citations

Role of Translocation in the Activation and Function of Protein Kinase B

Mirjana Andjelković, Dario R. Alessi, Roger Meier et al. · Journal of Biological Chemistry · 1997 · 1.1K citations · Full text

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

Matthias Frech, Mirjana Andjelković, Evan Ingley et al. · Journal of Biological Chemistry · 1997 · 442 citations · Full text

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

Ute Krengel, Ilme Schlichting, Anna Scherer et al. · Cell · 1990 · 393 citations

Signal Switch Molecules, Molecular Regulation, Molecular Biology +7

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

Marta Amaral, Daria B. Kokh, Jörg Bomke et al. · Nature Communications · 2017 · 283 citations · Full text