Bertrand Heckmann

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- <i>a</i> ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

Nicolas Desroy, Christopher Housseman, Xavier Bock et al. · Journal of Medicinal Chemistry · 2017 · 139 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +8

Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer

Geertje van der Horst, Christel van den Hoogen, Jeroen T. Buijs et al. · Neoplasia · 2011 · 107 citations · Full text

Medicine, Molecular Biology, Oncology +17

Sulfonylureas and Sulfonylcarbamates as New Non-Tetrazole Angiotensin II Receptor Antagonists. Discovery of a Highly Potent Orally Active (Imidazolylbiphenylyl)sulfonylurea (HR 720)

Pierre Deprez, Jacques Guillaume, R. H. A. Becker et al. · Journal of Medicinal Chemistry · 1995 · 64 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-<i>a</i>]pyridine Series of Autotaxin Inhibitors

Agnès Joncour, Nicolas Desroy, Christopher Housseman et al. · Journal of Medicinal Chemistry · 2017 · 62 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression

Hildegonda P. H. Naber, Eliza Wiercinska, Evangelia Pardali et al. · Cellular Oncology · 2011 · 61 citations · Full text

Life Sciences, Cell Biology, Oncology +16