Holly J. Clarke

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

Mark J. Solloway, Azadeh Madjidi, Chunyan Gu et al. · Cell Reports · 2015 · 190 citations · Full text

Human Growth, Glucagon Signaling, Mtor-dependent Regulation +23

Molecular basis for negative regulation of the glucagon receptor

Christopher M. Koth, Jeremy Murray, Susmith Mukund et al. · Proceedings of the National Academy of Sciences · 2012 · 127 citations · Full text

Crystal Structure, Molecular Physiology, Signal Transduction +15

MBX-102/JNJ39659100, a Novel Peroxisome Proliferator-Activated Receptor-Ligand with Weak Transactivation Activity Retains Antidiabetic Properties in the Absence of Weight Gain and Edema

Francine M. Gregoire, Fang Zhang, Holly J. Clarke et al. · Molecular Endocrinology · 2009 · 79 citations · Full text

Pharmacotherapy, Insulin Signaling, Oxidative Stress +17

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

Susmith Mukund, Yonglei Shang, Holly J. Clarke et al. · Journal of Biological Chemistry · 2013 · 36 citations · Full text

Autoimmune Disease, G Protein-coupled Receptor, Medicine +11

MBX‐102/JNJ39659100, a Novel Non‐TZD Selective Partial PPAR‐<i>γ</i> Agonist Lowers Triglyceride Independently of PPAR‐<i>α</i> Activation

Apurva Chandalia, Holly J. Clarke, L. Edward Clemens et al. · PPAR Research · 2009 · 22 citations · Full text