David O. Clarke

Pharmacokinetics of 2-Methoxyethanol and 2-Methoxyacetic Acid in the Pregnant Mouse: A Physiologically Based Mathematical Model

David O. Clarke, Barbara A. Elswick, Frank Welsch et al. · Toxicology and Applied Pharmacology · 1993 · 59 citations

2-Methoxyacetic Acid, Pharmacokinetic Modeling, Pharmacological Study +10

2-Methoxyacetic acid dosimetry-teratogenicity relationships in CD-1 mice exposed to 2-methoxyethanol

David O. Clarke, Joan M. Duignan, Frank Welsch · Toxicology and Applied Pharmacology · 1992 · 42 citations

Pharmacological Study, Medicine, Toxicology +6

The Use of Minipigs for Preclinical Safety Assessment by the Pharmaceutical Industry

Curtis Colleton, David Brewster, Anne Chester et al. · Toxicologic Pathology · 2016 · 42 citations

Traditional Dog, Toxicology Testing, Laboratory Animal Study +19

Strategies and Recommendations for Using a Data‐Driven and Risk‐Based Approach in the Selection of First‐in‐Human Starting Dose: An International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Assessment

Michael W. Leach, David O. Clarke, Sherri Dudal et al. · Clinical Pharmacology & Therapeutics · 2020 · 30 citations

Patient Selection, Pharmacotherapy, Drug Assessment +16

Protection against 2-methoxyethanol-induced teratogenesis by serine enantiomers: Studies of potential alteration of 2-methoxyethanol pharmacokinetics

David O. Clarke, Charles A. Mebus, Frederick J. Miller et al. · Toxicology and Applied Pharmacology · 1991 · 26 citations

Potential Alteration, Pharmacological Study, Medicine +6