David Le

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Chao Wang, Li Fan, Rabia R. Khawaja et al. · Nature Communications · 2022 · 317 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

Tara E. Tracy, Peter Sohn, Sakura Minami et al. · Neuron · 2016 · 276 citations

Life Sciences, Neurobiology, Neuroscience +16

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Faten A. Sayed, Maria A. Telpoukhovskaia, Lay Kodama et al. · Proceedings of the National Academy of Sciences · 2018 · 266 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

Lihong Zhan, Grietje Krabbe, Fei Du et al. · PLoS Biology · 2019 · 167 citations · Full text

Medicine, Neurobiology, Neuroscience +16

AD-linked R47H-<i>TREM2</i>mutation induces disease-enhancing microglial states via AKT hyperactivation

Faten A. Sayed, Lay Kodama, Li Fan et al. · Science Translational Medicine · 2021 · 156 citations · Full text

Life Sciences, Neurology, Neuroscience +17