Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Chao Wang, Li Fan, Rabia R. Khawaja, +16

Nature Communications

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

Joe C. Udeochu, Sadaf Amin, Yige Huang, +26

Nature Neuroscience

Tau ActivationImmunologyNeuroinflammationInflammationSynapse Integrity +16

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

Peter Sohn, Cindy Huang, Rui Yan, +16

Neuron

Knockout MouseSynaptic PlasticityExcitability HomeostasisDevelopmental BiologyDegenerative Pathology +7

Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Sheng‐Han Kuo, Inmaculada Tasset, Melody M. Cheng, +20

Science Advances

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo

Sandy Hung, Vicki Chrysostomou, Li Fan, +13

Investigative Ophthalmology & Visual Science

AD-linked R47H-<i>TREM2</i>mutation induces disease-enhancing microglial states via AKT hyperactivation

Faten A. Sayed, Lay Kodama, Li Fan, +37

Science Translational Medicine

DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis

Hong‐Zhong Zhou, Li Fan, Sheng‐Tao Cheng, +11

Hepatology

Cognitive Function and All-Cause Mortality in Maintenance Hemodialysis Patients

David A. Drew, Daniel E. Weiner, Hocine Tighiouart, +7

American Journal of Kidney Diseases

HemodialysisMedicineDementiaCognitive DysfunctionKidney Failure +6

A discrete shuffled frog-leaping algorithm to identify influential nodes for influence maximization in social networks

Jianxin Tang, Ruisheng Zhang, Ping Wang, +3

Knowledge-Based Systems

Computational Social ScienceNetwork ScienceEngineeringNetwork AlgorithmInfluence Maximization +10

Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue

Simon A. Hardwick, Wen Hu, Anoushka Joglekar, +27

Nature Biotechnology