Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

Sang‐Won Min, Xu Chen, Tara E. Tracy, +19

Nature Medicine

Neurodegenerative DiseasesAlzheimer's DiseaseDementiaDegenerative DiseaseDegenerative Pathology +7

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

Chao Wang, Michael E. Ward, Robert Y. Chen, +10

Stem Cell Reports

Neurochemical BiomarkersSocial SciencesTotal Tau LevelsIsogenic Ipsc LineAlzheimer's Disease +17

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesús Madero‐Pérez, Danielle L. Swaney, +27

Cell

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

Seo-Hyun Cho, Jason Chen, Faten A. Sayed, +11

Journal of Neuroscience

AgingImmunologyBiogerontologyBrain AgesSirt1 Deficiency +14

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

Tara E. Tracy, Peter Sohn, Sakura Minami, +12

Neuron

Neurodegenerative DiseasesSynaptic PlasticitySignal TransductionAlzheimer's DiseaseSynaptic Transmission +8

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

Benjamı́n Caballero, Mathieu Bourdenx, Enrique Luengo, +18

Nature Communications

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy

Sang‐Won Min, Peter Sohn, Yaqiao Li, +7

Journal of Neuroscience

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

Peter Sohn, Tara E. Tracy, Hye-In Son, +6

Molecular Neurodegeneration

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

Peter Sohn, Cindy Huang, Rui Yan, +16

Neuron

Knockout MouseSynaptic PlasticityExcitability HomeostasisDevelopmental BiologyDegenerative Pathology +7

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation

Lea T. Grinberg, Xuehua Wang, Chao Wang, +10

Acta Neuropathologica

Autoimmune DiseaseAllergyDisease MechanismTau AcetylationPathogenesis +5