Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

Leilei Zhong, Lutian Yao, Robert J. Tower, +19

eLife

Bone Marrow EnvironmentSingle Cell TranscriptomicsAdult Stem CellTranscriptomics TechnologyMarrow Adipose Tissue +18

Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice

Yanqing Gong, Erika Hart, Aleksey Shchurin, +1

Journal of Clinical Investigation

Lung InflammationImmunologyCell DeathCellular PhysiologyInflammation +15

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

Qirui Wang, Zhenqiang He, Menggui Huang, +15

Nature Communications

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Tianrun Liu, Wenjuan Ma, Haineng Xu, +10

Nature Communications

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Fan Yang, Zhenqiang He, Hao Duan, +15

Nature Communications

Synergistic ImmunotherapyImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +22

Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

Menggui Huang, Duo Zhang, Janet Y. Wu, +13

Science Translational Medicine

Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma

Wenjuan Ma, Yanling Wang, Rongxin Zhang, +10

Nature Cancer

Neuro-oncologyCancer ImmunosurveillanceGliomaCar-t ImmunotherapyVascular Microenvironment +9

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

Menggui Huang, Tianrun Liu, Peihong Ma, +15

Journal of Clinical Investigation

Cancer BiologyGliomaTumor BiologyAngiogenesisCancer Cell Biology +14

Circulating Glioma Cells Exhibit Stem Cell-like Properties

Tianrun Liu, Haineng Xu, Menggui Huang, +11

Cancer Research

PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

Duo Zhang, Albert M. Li, Guanghui Hu, +17

Cell Metabolism

Neuro-oncologyCell TherapyCancer ImmunosurveillanceGliomaImmunology +4