Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

Leilei Zhong, Lutian Yao, Robert J. Tower, +19

eLife

Bone Marrow EnvironmentSingle Cell TranscriptomicsAdult Stem CellTranscriptomics TechnologyMarrow Adipose Tissue +18

Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss

Wei Yu, Leilei Zhong, Lutian Yao, +13

Journal of Clinical Investigation

Targeting cartilage EGFR pathway for osteoarthritis treatment

Yulong Wei, Lijun Luo, Tao Gui, +18

Science Translational Medicine

Correlation between Gene Expression and Osteoarthritis Progression in Human

Leilei Zhong, Xiaobin Huang, Marcel Karperien, +1

International Journal of Molecular Sciences

InflammationGradual DegradationRheumatoid DisorderMusculoskeletal ResearchAutoimmune Disease +13

Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy

Tao Gui, Lijun Luo, Bonirath Chhay, +9

Biomaterials

NanomedicineEngineeringPolymer-drug ConjugateOsteoarthritisNano-drug Delivery +5

T Cell Factor 4 Is a Pro-catabolic and Apoptotic Factor in Human Articular Chondrocytes by Potentiating Nuclear Factor κB Signaling

Bin Ma, Leilei Zhong, Clemens van Blitterswijk, +2

Journal of Biological Chemistry

Inflammatory Lung DiseaseHuman ChondrocytesImmune RegulationImmunologyPathology +21

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

Leilei Zhong, Jiawei Lu, Jiankang Fang, +16

eLife

The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells

Xiaobin Huang, Leilei Zhong, Jan Hendriks, +2

International Journal of Molecular Sciences

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

Leilei Zhong, Xiaobin Huang, Emilie Dooms Rodrigues, +5

Stem Cells and Development

Human ChondrocytesAdult Stem CellImmunologyFrzb Regulate ChondrogenesisRegenerative Medicine +17

Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation‐induced osteoporosis

Abhishek Chandra, Luqiang Wang, Tiffany Young, +8

The FASEB Journal

SclerostinBone AtrophyProteasome Inhibitor BortezomibMolecular BiologyCell Death +21