Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Anna Galkin, Jonathan S. Melnick, Sung Joon Kim, +14

Proceedings of the National Academy of Sciences

Drug TargetImmunologyCell DeathPharmacotherapyConstitutive Overexpression +20

Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme

Michael A. Kalchman, Rona K. Graham, Gang Xia, +7

Journal of Biological Chemistry

Crystal Structure of the Human Ubiquitin-like Protein NEDD8 and Interactions with Ubiquitin Pathway Enzymes

Frank G. Whitby, Gang Xia, Cecile M. Pickart, +1

Journal of Biological Chemistry

An efficient rapid system for profiling the cellular activities of molecular libraries

Jonathan S. Melnick, Jeff Janes, Sung Joon Kim, +24

Proceedings of the National Academy of Sciences

Cellular AssaysCellular ActivitiesDrug TargetCompound ProfilerKinase Inhibitors +26

Directed evolution of novel polymerase activities: Mutation of a DNA polymerase into an efficient RNA polymerase

Gang Xia, Liangjing Chen, Takashi Sera, +3

Proceedings of the National Academy of Sciences

Viral Polymerase StructureGeneticsMolecular BiologyMolecular GeneticsSf Library +17

Functional Textiles with Smart Properties: Their Fabrications and Sustainable Applications

Yabin Zhang, Xiaohu Xia, Kaikai Ma, +8

Advanced Functional Materials

3D TextilesSmart TextileEngineeringTechnical TextileWearable Technology +20

A General Strategy for Creating “Inactive-Conformation” Abl Inhibitors

Okram Barun, A. S. Nagle, Francisco Adrián, +11

Chemistry & Biology

Molecular PharmacologyGeneral StrategyMedicineRational Drug DesignPharmacotherapy +4

Mussel‐Inspired Design of a Self‐Adhesive Agent for Durable Moisture Management and Bacterial Inhibition on PET Fabric

Yuanfeng Wang, Gang Xia, Hui Yu, +4

Advanced Materials

Structure and Function of Ubiquitin Conjugating Enzyme E2-25K:  The Tail Is a Core-Dependent Activity Element

Margaret T. Haldeman, Gang Xia, Eileen M. Kasperek, +1

Biochemistry

Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast

Denise Hanway, Jodie K. Chin, Gang Xia, +3

Proceedings of the National Academy of Sciences

Dna DamageGeneticsGenomic MechanismMolecular BiologyMolecular Genetics +15