Tim Young

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

John P. Huggins, Trevor Smart, Stephen Langman et al. · Pain · 2012 · 373 citations

Medicine, Pharmacology, Pharmacotherapy +17

Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

Thomas Ryckmans, Martin P. Edwards, Val A. Horne et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 269 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

Kay Ahn, Sarah E. Smith, Marya Liimatta et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 231 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Glucose Promotes Stress Resistance in the Fungal Pathogen<i>Candida albicans</i>

Alexandra Rodaki, Iryna Bohovych, Brice Enjalbert et al. · Molecular Biology of the Cell · 2009 · 190 citations · Full text

Life Sciences, Microbiology, Molecular Biology +17

Assessment of the pharmacology and tolerability of PF‐04457845, an irreversible inhibitor of fatty acid amide hydrolase‐1, in healthy subjects

Gai Ling Li, Helen Winter, Rosalin Arends et al. · British Journal of Clinical Pharmacology · 2011 · 124 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +9