Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

Y. Eugene Chin, Motoo Kitagawa, Keisuke Kuida, +2

Molecular and Cellular Biology

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

Xin‐Yuan Fu, Daniel S. Kessler, Susan A. Veals, +2

Proceedings of the National Academy of Sciences

Molecular RegulationMolecular BiologyInterferon AlphaTranscriptional RegulationInterferon-stimulated Response Element +17

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

Susan A. Veals, Christian Schindler, Debra G. B. Leonard, +4

Molecular and Cellular Biology

Isgf3 AlphaGeneticsAlpha-interferon-responsive Transcription FactorMolecular BiologyGene Regulatory Network +15

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

Daniel S. Kessler, Susan A. Veals, Xin‐Yuan Fu, +1

Genes & Development

Isgf3 AlphaCellular PhysiologyIfn-stimulated Response ElementMultimeric Transcriptional ActivatorTranscriptional Regulation +16

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

Xin‐Yuan Fu, Jiaojiao Zhang

Cell

Transcriptional RegulationDevelopmental BiologySignal TransductionSignaling PathwayGene Regulation +7

IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression.

Xiulong Xu, Xin‐Yuan Fu, Janet M.D. Plate, +1

PubMed

Stat1 ProteinApoptosisImmunologyCell DeathCell Proliferation +14

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans

Luang Xu, Xinyu Liu, Na Sheng, +8

Journal of Biological Chemistry

Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation

Frank E. Jones, Thomas Welte, Xin‐Yuan Fu, +1

The Journal of Cell Biology

Breast OncologyDevelopmental BiologySignal TransductionLactationSignaling Pathway +13

A genetic and developmental pathway from STAT3 to the OCT4–NANOG circuit is essential for maintenance of ICM lineages in vivo

Dang Vinh, Jun Ueda, Daniel M. Messerschmidt, +15

Genes & Development

Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype

Charlie Mantel, Steven Messina‐Graham, Akira Moh, +4

Blood