Ayush Kishore

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Xiaodong Feng, Nadia Arang, Damiano Cosimo Rigiracciolo et al. · Cancer Cell · 2019 · 243 citations · Full text

Medicine, Genetics, Molecular Biology +14

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

Thijs J. Hagenbeek, Marc Hafner, Rana Mroue et al. · Nature Cancer · 2023 · 195 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +17

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

Ayush Kishore, Ryan H. Purcell, Zahra Nassiri Toosi et al. · Journal of Biological Chemistry · 2015 · 146 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i> -Driven Uveal Melanoma

Justine S. Paradis, Monica Acosta, Robert Saddawi‐Konefka et al. · Clinical Cancer Research · 2021 · 76 citations · Full text

Medicine, Oncology, Ophthalmology +17

Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling

Ayush Kishore, Randy A. Hall · Journal of Biological Chemistry · 2017 · 40 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15