Jiuyu Liu

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

Richard Lee, Julian G. Hurdle, Jiuyu Liu et al. · Nature Medicine · 2014 · 192 citations · Full text

Pharmaceutical Science, Medicine, Semisynthetic Antituberculosis Agents +10

Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

Yi Miao, Jennifer L. Tenor, Dena L. Toffaletti et al. · Proceedings of the National Academy of Sciences · 2016 · 62 citations · Full text

Dead Tps2pd, Biosynthesis, Cellular Enzymology +15

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

David F. Bruhn, Michaël Scherman, Jiuyu Liu et al. · Scientific Reports · 2015 · 60 citations · Full text

Structure–Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions

Jiuyu Liu, David F. Bruhn, Robin B. Lee et al. · ACS Infectious Diseases · 2016 · 57 citations · Full text

Antimicrobial Chemotherapy, Chemical Biology, Structure–activity Relationships +17

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

Gregory T. Robertson, Michaël Scherman, David F. Bruhn et al. · Journal of Antimicrobial Chemotherapy · 2016 · 50 citations · Full text