Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Mehrdad Matloubian, Charles G. Lo, Guy Cinamon, +6

Nature

Thymus BiologyAutoimmune DiseaseImmunologyImmune RegulationLymphatic System +9

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

Lawrence R. Shiow, David B. Rosen, Naděžda Brdičková, +5

Nature

InflammationAdaptive Immune SystemViral ImmunityImmune RegulationImmunology +12

Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

Rajita Pappu, Susan R. Schwab, Ivo Cornelissen, +8

Science

T-regulatory CellImmunologyImmune RegulationBlood CellImmunologic Mechanism +19

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

Susan R. Schwab, João P. Pereira, Mehrdad Matloubian, +3

Science

ImmunologyImmune RegulationImmunologic MechanismAntigen ProcessingImmunotherapy +19

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

Trung H.M. Pham, Ying Xu, Irina Grigorova, +6

The Journal of Experimental Medicine

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone

Guy Cinamon, Mehrdad Matloubian, Matthew J. Lesneski, +5

Nature Immunology

Signal TransductionCell RegulationCell InteractionCell TraffickingSplenic Marginal Zone +6

Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation

Tri Giang Phan, Jesse A. Green, Elizabeth Gray, +2

Nature Immunology

Immune Complex RelayAutoimmune DiseaseHumoral ResponseImmunologyImmunodominance +9

T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow

Craig N. Jenne, Anselm Enders, Richard Rivera, +14

The Journal of Experimental Medicine

Lymphocyte DevelopmentT-regulatory CellImmunologyNk CellsImmunologic Mechanism +15

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

Charles G. Lo, Ying Xu, Richard L. Proia, +1

The Journal of Experimental Medicine

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

Jagan Muppidi, Roland Schmitz, Jesse A. Green, +21

Nature

Tumor BiologyLymphoid NeoplasiaMedicineImmunologyTumor Suppressor +4