PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

Wenhao Jiang, Yunyun Jin, Shiwei Zhang, +12

Bone Research

An Iodine‐Chemisorption Binder for High‐Loading and Shuttle‐Free Zn–Iodine Batteries

Kexuan Wang, Heng Li, Zhu Xu, +9

Advanced Energy Materials

Materials ScienceChemical EngineeringEnergy MaterialEngineeringBattery Electrode Materials +13

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

Weiqiang Lü, Weiwei Yu, Jiacheng He, +18

EMBO Molecular Medicine

8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models

Zhe Cheng, An-feng Chen, Fang Wu, +8

Bioorganic & Medicinal Chemistry

Improved BioavailabilityMetabolic SyndromeBiochemistryMedicineDiabetic Mouse Models +6

Enhancing degradation of atrazine by Fe-phenol modified biochar/ferrate(VI) under alkaline conditions: Analysis of the mechanism and intermediate products

Yu Cao, Shanqing Jiang, Xudong Kang, +3

Chemosphere

Chemical EngineeringBiocharEnvironmental ChemistryIntermediate ProductsEngineering +8

Discovery and Characterization of 1<i>H</i>-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy

Junjie Yang, Weiwei Yu, Longlong Hu, +10

Journal of Medicinal Chemistry

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Yunyun Jin, Qianqian Liu, Peng Chen, +17

Cell Discovery

Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Hankun Zhang, Werner Tückmantel, J. Brek Eaton, +12

Journal of Medicinal Chemistry

New Drug CandidatesSynaptic TransmissionPsychopharmacologyPeptide SciencePharmacotherapy +21

Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase 6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

Jay H. Kalin, Hankun Zhang, Sophie Gaudrel‐Grosay, +2

ChemMedChem

Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches

Zengrui Wu, Weiqiang Lü, Weiwei Yu, +9

Pharmacological Research

Systems PharmacologyBiochemistryG Protein-coupled ReceptorMedicineFunctional Selectivity +8