Diane P. Williams

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

Diane P. Williams, K Parker, Patricia Bacha et al. · Protein Engineering Design and Selection · 1987 · 235 citations

Life Sciences, Immunology, Molecular Biology +14

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

Patricia Bacha, Diane P. Williams, Cory A. Waters et al. · The Journal of Experimental Medicine · 1988 · 220 citations · Full text

Life Sciences, Immunology, Pharmacology +16

Structure/function analysis of interleukin-2-toxin (DAB486-IL-2). Fragment B sequences required for the delivery of fragment A to the cytosol of target cells.

Diane P. Williams, Catherine E. Snider, Terry B. Strom et al. · Journal of Biological Chemistry · 1990 · 185 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194

Diane P. Williams, Zhe Wen, Rachael Watson et al. · Journal of Biological Chemistry · 1990 · 81 citations · Full text

Life Sciences, Cell Biology, Immunology +13

Design, synthesis and expression of a human interteukin-2 gene incorporating the codon usage bias found in highly expressed Escherichia coli genes

Diane P. Williams, Dean A. Regier, Donna E. Akiyoshi et al. · Nucleic Acids Research · 1988 · 67 citations · Full text

Life Sciences, Genetics, Molecular Biology +12