Charles Q. Huang

Design and Synthesis of a Series of Non-Peptide High-Affinity Human Corticotropin-Releasing Factor₁ Receptor Antagonists

Chen Chen, Raymond Dagnino, Errol B. De Souza et al. · Journal of Medicinal Chemistry · 1996 · 137 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Discovery of Sodium <i>R</i>-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2<i>H</i>-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Chen Chen, Dongpei Wu, Zhiqiang Guo et al. · Journal of Medicinal Chemistry · 2008 · 119 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-<i>a</i>]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Chen Chen, Keith Wilcoxen, Charles Q. Huang et al. · Journal of Medicinal Chemistry · 2004 · 117 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

New methods for the synthesis of fluoroolefins via the palladium catalyzed cross-coupling reaction of 1-fluorovinyl halides with organoboranes and organostannanes

Chen Chen, Keith Wilcoxen, Charles Q. Huang et al. · Journal of Fluorine Chemistry · 2000 · 49 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

Design and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists

Raymond S. Gross, Zhiqiang Guo, Brian Dyck et al. · Journal of Medicinal Chemistry · 2005 · 46 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17