Yingjie Lai

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Sue J. Sohn, Kathy Barrett, Anne van Abbema et al. · The Journal of Immunology · 2013 · 126 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Lead identification of novel and selective TYK2 inhibitors

Jun Liang, Vickie Tsui, Anne van Abbema et al. · European Journal of Medicinal Chemistry · 2013 · 123 citations · Full text

Pharmacy, Chemical Biology, Chemistry +14

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Jun Liang, Anne van Abbema, Mercedesz Balázs et al. · Journal of Medicinal Chemistry · 2013 · 97 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

The synthesis and structure–activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors

Lloyd J. Simons, Bradley W. Caprathe, Michael J. Callahan et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 46 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Shuwen He, Zhixiong Ye, Peter H. Dobbelaar et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 23 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9