Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

Jiang Dai, Yi-Jiao Huang, Xinhua He, +24

Cell

Autoimmune DiseaseAutoantibody ProductionImmunologyAutoimmunityAutoantibodies +2

G3BP1 promotes DNA binding and activation of cGAS

Zhao-Shan Liu, Hong Cai, Wen Xue, +20

Nature Immunology

Transcriptional RegulationMolecular PhysiologyDna BindingMolecular RegulationNatural Sciences +7

5G-enabled ultra-sensitive fluorescence sensor for proactive prognosis of COVID-19

Jiuchuan Guo, Shuqin Chen, Shulin Tian, +6

Biosensors and Bioelectronics

Proactive PrognosisCovid-19 PandemicFluorescence ImagingRadiation OncologyCovid-19 +1

GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein

Ming Zhao, Yu Yu, Li-Ming Sun, +18

Nature Communications

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

Puyu Li, Ming Zhao, Amanda B. Parris, +2

Biochemical and Biophysical Research Communications

Breast OncologyOncologyMetformin-induced Growth InhibitionMedicineBreast Cancer Cells +9

The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA

Ming Zhao, Tian Xia, Jia‐Qing Xing, +21

EMBO Reports

Molecular RegulationNatural SciencesGeneticsRapid ResponsesDna Replication +7

RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

Zhao-Shan Liu, Ziyu Zhang, Hong Cai, +6

Cell & Bioscience

Loss of PICH promotes chromosome instability and cell death in triple-negative breast cancer

Yan Huang, Wanjin Li, Weiwei Yan, +17

Cell Death and Disease

Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway

Zhiying Guo, Ming Zhao, Erin W. Howard, +4

Oncotarget

Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform

Fuqiang Xing, Yucheng Liu, Shigao Huang, +26

Theranostics