Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Michio Kawano, Toshio Hirano, Tadashi Matsuda, +9

Nature

Hematological MalignancyImmunologyHematologyPathologyBlood Cell +5

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

Shizuo Akira, Hiroshi Isshiki, Takahisa Sugita, +6

The EMBO Journal

InflammationCytokineTranscriptional RegulationNuclear FactorImmunology +6

Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals

Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, +25

Nature Communications

Structural VariantsGeneticsGenetic EpidemiologyGenomicsGenetic Medicine +27

The Tohoku Medical Megabank Project: Design and Mission

Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, +53

Journal of Epidemiology

Tmm BirthFamily MembersEpidemiologic ResearchClinical SpecialtiesPopulation Health Sciences +19

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

Osamu Tanabe, Shizuo Akira, Taku Kamiya, +3

The Journal of Immunology

ImmunologyImmunologic MechanismMurine Il-6 GeneImmunogeneticsTranscriptional Regulation +16

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.

Hiroshi Isshiki, Shizuo Akira, Osamu Tanabe, +4

Molecular and Cellular Biology

Immune RegulationImmunologyImmunologic MechanismImmune SystemImmunotherapy +16

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

Fei Liu, Jae Lee, Huijun Wei, +4

Blood

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, +62

International Journal of Epidemiology

Cohort ProfileClinical PopulationGlobal HealthInternational HealthThree-generation Cohort Study +6

Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction

Lihong Shi, Shuaiying Cui, James Douglas Engel, +1

Nature Medicine

Developmental BiologyMolecular BiologyLysine-specific Demethylase 1Fetal Hemoglobin InductionHeme Homeostasis +1

Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, +80

Journal of Epidemiology