ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation

Mengshu Jia, Yue Xiao, Weixia Sun, +18

Science Advances

MitophagyMetabolic RemodelingCellular PhysiologyCell AutophagyTranscriptional Regulation +19

Co‐Delivery of Doxorubicin and siRNA with Reduction and pH Dually Sensitive Nanocarrier for Synergistic Cancer Therapy

Weicai Chen, Yuanyuan Yuan, Du Cheng, +3

Small

Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease

Li Xie, Yinan Zhang, Lingyan Xu, +25

Cell Metabolism

Energy HomeostasisEnergy MetabolismMolecular PhysiologyBiochemistryLactate Metabolism +9

Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor

Yejun Zou, Aoxue Wang, Li Huang, +23

Developmental Cell

Live CellsBiochemistryMedicineNatural SciencesIn Vivo System +8

Five Lec1 CHO cell mutants have distinct Mgat1 gene mutations that encode truncated N-acetylglucosaminyltransferase I

Weicai Chen

Glycobiology

Differential expression of carotenoid-related genes determines diversified carotenoid coloration in flower petal of Osmanthus fragrans

Yuanji Han, Xiaohui Wang, Weicai Chen, +4

Tree Genetics & Genomes

BiologyPlant BiologyPlant GeneticsCarotenoidBotany +10

Copolymer of poly(ethylene glycol) and poly(<scp>l</scp>-lysine) grafting polyethylenimine through a reducible disulfide linkage for siRNA delivery

Jingguo Li, Du Cheng, Tinghui Yin, +5

Nanoscale

Ethylene GlycolEngineeringGene DeliveryBiomedical EngineeringTumor Biology +17

USP18 promotes breast cancer growth by upregulating EGFR and activating the AKT/Skp2 pathway

Yawen Tan, Guanglin Zhou, Xianming Wang, +2

International Journal of Oncology

Breast Cancer GrowthBreast OncologyAkt/skp2 PathwayCancer BiologyMammary Gland Development +16

miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer

Liangfeng Guo, Jianhui Yuan, Ni Xie, +4

Molecular Medicine Reports

Breast OncologyEngineeringPathologyCancer BiologyMammary Gland Development +20

Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Weicai Chen, Ye Kuang, Haibo Qiu, +13

Cancer Research