ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation

Mengshu Jia, Yue Xiao, Weixia Sun, +18

Science Advances

MitophagyMetabolic RemodelingCellular PhysiologyCell AutophagyTranscriptional Regulation +19

Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease

Li Xie, Yinan Zhang, Lingyan Xu, +25

Cell Metabolism

Energy HomeostasisEnergy MetabolismMolecular PhysiologyBiochemistryLactate Metabolism +9

Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia

Chiqi Chen, Xiaoxin Hao, Xiaoyun Lai, +14

Science Advances

PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21

Xiaoye Liu, Feifei Zhang, Yaping Zhang, +22

Cell Reports

A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells

Li Xie, Changcheng Zhang, Xiaopei Xu, +6

Nucleic Acids Research

Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models

Xiaoxiao He, Jiangbo Wan, Xiaona Yang, +14

Journal of Clinical Investigation

Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche

Xiaoxin Hao, Hao Gu, Chiqi Chen, +15

Cell Metabolism

Symmetric Cell DivisionDevelopmental BiologyCell DivisionEndosteal NicheBiological Microenvironments +8

MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells

Hao Gu, Chiqi Chen, Xiaoxin Hao, +18

Blood

Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells

Dan Huang, Changcheng Zhang, Ming Xiao, +20

Proceedings of the National Academy of Sciences

Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors

Aoxue Wang, Yejun Zou, Shuning Liu, +13

Nature Protocols

Wearable BiosensorsLactate Metabolic DynamicsEngineeringImplantable SensorBiosensing Systems +12