Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia

Yosuke Ogoshi, Takuya Matsui, Ikuo MITANI, +12

ACS Medicinal Chemistry Letters

Development of Inhalable Nanocrystalline Solid Dispersion of Tranilast for Airway Inflammatory Diseases

Satomi Onoue, Yosuke Aoki, Yohei Kawabata, +5

Journal of Pharmaceutical Sciences

Materials ScienceNanomedicineEngineeringNanomaterialsTherapeutic Nanomaterials +5

JTZ-951 (enarodustat), a hypoxia-inducibe factor prolyl hydroxylase inhibitor, stabilizes HIF-α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor

Kenji Fukui, Yuichi Shinozaki, Hatsue Kobayashi, +7

European Journal of Pharmacology

InflammationEndothelial Cell PathobiologyInduces ErythropoiesisPhysiologyHypoxia (Medicine) +9

ESTABLISHMENT AND CHARACTERIZATION OF A HUMAN B CELL LINE FROM THE LUNG TISSUE OF A PATIENT WITH SCLERODERMA; EXTRAORDINARY HIGH LEVEL OF IL-6 SECRETION BY STIMULATED FIBROBLASTS

Kazuo Kondo, Tadashi Okada, Takuya Matsui, +7

Cytokine

InflammationCytokineInflammatory Lung DiseaseAutoimmune DiseaseLung Inflammation +12

Discovery of 6-Phenylpyrimido[4,5-<i>b</i>][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents

Brian M. Fox, Kazuyuki Sugimoto, Kiyosei Iio, +29

Journal of Medicinal Chemistry

Vivo EfficacyPharmacotherapySelective Acyl CoaChemical BiologyPharmaceutical Chemistry +18

Lansiumamide B and SB-204900 isolated from Clausena lansium inhibit histamine and TNF-α release from RBL-2H3 cells

Takuya Matsui, Chihiro Ito, Hiroshi Furukawa, +2

Inflammation Research

Medicinal ChemistryLansiumamide BMedicineImmunologyTnf-α Release +5

Effect of natsudaidain isolated from<i>Citrus</i>plants on TNF-α and cyclooxygenase-2 expression in RBL-2H3 cells

Takuya Matsui, Chihiro Ito, Masataka Itoigawa, +2

Journal of Pharmacy and Pharmacology

Isolation of 6,7-Demethylenedesoxypodophyllotoxin from Hernandia ovigera.

Chihiro Ito, Takuya Matsui, Tian-Shung Wu, +1

Chemical and Pharmaceutical Bulletin

BiologyBioorganic ChemistryBiochemistryBotanyNatural Sciences +12

Three phlorotannins from Sargassum carpophyllum are effective against the secretion of allergic mediators from antigen-stimulated rat basophilic leukemia cells

Takuya Matsui, Chihiro Ito, Masataka Itoigawa, +1

Food Chemistry

PhytoalexinAllergyMedicineImmunologyAllergic Mediators +5

Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats

Satomi Onoue, Takuya Matsui, Yosuke Aoki, +4

European Journal of Pharmaceutical Sciences

AsthmaSelf-assembled Micellar FormulationPharmaceutical ScienceExperimental Asthma/copd-model RatsAnti-inflammatory +8