Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Ningning Liu, Xiaofen Li, Hongbiao Huang, +20

Oncotarget

STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome

Yang Xiao, Chong Zhao, Yang Tai, +9

Redox Biology

Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

Xianping Shi, Xin Chen, Xiaofen Li, +13

Clinical Cancer Research

RNA aggregates harness the danger response for potent cancer immunotherapy

Héctor R. Méndez‐Gómez, Anna DeVries, Paul Castillo, +54

Cell

Cancer ImmunosurveillanceDanger ResponseMedicineImmunologyImmunoediting +8

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Xiaofen Li, Shouting Liu, Hongbiao Huang, +26

Cell Reports

ProteasomeGliomaTumor BiologyAnti-cancer AgentProteomics +18

Cross-Talk Between Butyric Acid and Gut Microbiota in Ulcerative Colitis Following Fecal Microbiota Transplantation

Haoming Xu, Hongli Huang, Jing Xu, +7

Frontiers in Microbiology

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Xin Chen, Xianping Shi, Chong Zhao, +13

Oncotarget

ApoptosisImmunologyCell DeathAnti-rheumatic Agent AuranofinTumor Biology +18

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

Ningning Liu, Chunjiao Liu, Xiaofen Li, +17

Scientific Reports

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects <i>in vitro</i> and <i>in vivo</i>

Hongbiao Huang, Yuning Liao, Ningning Liu, +13

Oncotarget

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

Chong Zhao, Xin Chen, Dan Zang, +16

Oncogene

Proteasomal Deubiquitinase InhibitorNovel Nickel ComplexCancer TherapyBiochemistryNatural Sciences +7