Mutsuko Sakai

Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors

Yohei Ikuma, Hitoshi Hochigai, Hidenori Kimura et al. · Bioorganic & Medicinal Chemistry · 2012 · 39 citations · Full text

Medicinal Chemistry, Biochemistry, Antiparasitic Agent +8

SMP-534 inhibits TGF-β-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis

Eiji Sugaru, Mutsuko Sakai, Kazuhiko Horigome et al. · American Journal of Physiology-Renal Physiology · 2005 · 24 citations

Glomerular Disease, Renal Pathology, Immunology +23

Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore

Yukihiro Nishio, Hidenori Kimura, Shinya Tosaki et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 23 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +8

Discovery of Novel<i>N</i>-Substituted Oxindoles as Selective M₁and M₄Muscarinic Acetylcholine Receptors Partial Agonists

Takaaki Sumiyoshi, Takeshi Enomoto, Kentaro Takai et al. · ACS Medicinal Chemistry Letters · 2013 · 21 citations · Full text

2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): A potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A

Yukihiro Nishio, Hidenori Kimura, Naoyuki Sawada et al. · Bioorganic & Medicinal Chemistry · 2011 · 20 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +10