Hitoshi Hochigai

Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors

Yohei Ikuma, Hitoshi Hochigai, Hidenori Kimura et al. · Bioorganic & Medicinal Chemistry · 2012 · 39 citations · Full text

Medicinal Chemistry, Biochemistry, Antiparasitic Agent +8

Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453

Tetsuya Kohno, Hitoshi Hochigai, Eiki Yamashita et al. · Biochemical and Biophysical Research Communications · 2006 · 31 citations

Catalytic Domain, Biochemistry, Natural Sciences +8

Chronic administration of DSP‐7238, a novel, potent, specific and substrate‐selective DPP IV inhibitor, improves glycaemic control and <i>β</i> ‐cell damage in diabetic mice

Yoshikazu Furuta, M. Horiguchi, Eiji Sugaru et al. · Diabetes Obesity and Metabolism · 2009 · 18 citations

Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: Use of a carboxylate prodrug to improve bioavailability

Yohei Ikuma, Hitoshi Hochigai, Hidenori Kimura et al. · Bioorganic & Medicinal Chemistry · 2014 · 15 citations · Full text

Carboxylate Prodrug, Medicinal Chemistry, Pharmaceutical Science +9