Keiichi Higuchi

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T

Hironobu Naiki, Keiichi Higuchi, Masanori Hosokawa et al. · Analytical Biochemistry · 1989 · 1.2K citations

Fluorometric Determination, Alzheimer's Disease, Engineering +10

Senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated Senescence

Toshio Takeda, Masanori Hosokawa, Keiichi Higuchi · Journal of the American Geriatrics Society · 1991 · 372 citations

Lifespan Extension, Developmental Biology, Aging +5

Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.

Mutsumi Matsushita, Tadao Tsuboyama, Rinshi S. Kasai et al. · PubMed · 1986 · 235 citations · Full text

Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)

Masanori Hosokawa, Ryuichi Kasai, Keiichi Higuchi et al. · Mechanisms of Ageing and Development · 1984 · 221 citations

Developmental Biology, Aging, Longevity +6

Kinetic analysis of amyloid fibril polymerization in vitro.

Hironobu Naiki, Keiichi Higuchi, K Nakakuki et al. · PubMed · 1991 · 194 citations