23:T485,The development of new antimicrobial agents capable of curing drug-resistant bacteria-induced infections is becoming a major challenge to the global healthcare system. To develop antimicrobials with new molecular entities, a series of novel carbazole-based compounds were designed and synthesized by biomimicking the structural properties and biological function of antimicrobial peptides. Compound 29 was selected as a lead compound from the structure-activity relationship analyses and biological activity evaluation. Compound 29 showed excellent antimicrobial activity against Gram-positive bacteria (MICs = 0.78-1.56 μg/mL), poor hemolytic activity (HC₅₀ > 200 μg/mL), and low cytotoxicity to mammalian cells. Compound 29 had fast bactericidal properties and effectively prevented bacterial resistance in laboratory simulations. Antibacterial mechanism studies revealed that compound 29 directly destroyed bacterial cell membranes, leading to bacterial deaths. Importantly, compound 29 displayed an excellent efficacy in a murine bacterial keratitis model caused by Staphylococcus aureus ATCC29213.24:T453,The concept of school climate has been an important topic for education and it has been studied extensively over the past several decades. One of the challenges in such a research effort is to develop instruments that effectively and efficiently measure the construct. Literature has documented a number of school climate instruments, most of which target students’ perceptions. A review of recent literature on school climate suggests that it is imperative to assess teachers’ perceptions of school climate. The purpose of this study was to examine the factor structure and reliability of a revised version of a teacher survey instrument designed to measure school climate. Based on the data from a comprehensive character education project implemented in an urban school district in 2007 ( n = 380), 2008 ( n = 305), and 2010 ( n = 277), results of exploratory and confirmatory factor analysis revealed a seven-factor structure across 3 years, indicating a stable factor structure of the revised form. The scales in this abbreviated form demonstrated similar reliability to those of the original form.

#	Concept	H-Index	Publications	Citations
1	Medicine	4	4	243
2	Biochemistry	2	2	77
3	Education	1	1	29
4	Health Sciences	1	1	64
5	Behavioral Sciences	1	1	29

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