Hongmei Xu

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

Huazhang An, Jin Hou, Jun Zhou et al. · Nature Immunology · 2008 · 253 citations

Transcriptional Regulation, Signal Transduction, Signaling Pathway +10

Involvement of ERK, p38 and NF‐κB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells

Huazhang An, Yizhi Yu, Minghui Zhang et al. · Immunology · 2002 · 236 citations · Full text

Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism

Huazhang An, Hongmei Xu, Minghui Zhang et al. · Blood · 2005 · 138 citations · Full text

Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-κB, ERK and p38 MAPK signal pathways

Huazhang An, Hongmei Xu, Yizhi Yu et al. · Immunology Letters · 2002 · 120 citations

Inflammation, Mapk Signal Pathways, Molecular Immunology +14

TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation

Cheng Qian, Xiaodong Jiang, Huazhang An et al. · Blood · 2006 · 97 citations