Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

Huazhang An, Jin Hou, Jun Zhou, +6

Nature Immunology

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationRig-i-activated Production +8

Blockade of Human Cardiac Potassium Channel Human Ether-a-go-go-Related Gene (HERG) by Macrolide Antibiotics

Walter A. Volberg, Bryan Koci, Wei-guo Su, +2

Journal of Pharmacology and Experimental Therapeutics

Pentamidine reduces <i>hERG</i> expression to prolong the QT interval

Jason Cordes, Zhuoqian Sun, David B. Lloyd, +5

British Journal of Pharmacology

Molecular PharmacologyTranslational MedicineAntiprotozoal AgentPharmaceutical ScienceHyperpolarization (Biology) +13

Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-κB activation and enhancing SOCS1 expression

Li Su, Yixi Sun, Feng Ma, +3

Immunology Letters

InflammationToll-like ReceptorsCytokineInnate Immune SystemImmune Regulation +11

Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment

Hongzhen Bai, Jianwei Wang, Chi Uyen Phan, +6

Nature Communications

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Qingqing Li, Zhihao Lü, Li Yang, +10

Asian Pacific Journal of Cancer Prevention

QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome

Xian Chen, Jessica D Cass, Jenifer A. Bradley, +5

British Journal of Pharmacology

Regional upregulation of Kv2.1-encoded current,<i>I</i> _K,slow2, in Kv1DN mice is abolished by crossbreeding with Kv2DN mice

Jun Zhou, Sodikdjon A. Kodirov, Mitsunobu Murata, +3

American Journal of Physiology-Heart and Circulatory Physiology

TAOK1 negatively regulates IL-17-mediated signaling and inflammation

Zhaoru Zhang, Zhen Tang, Xianwei Ma, +7

Cellular and Molecular Immunology

InflammationCytokineAutoimmune DiseaseImmune RegulationImmunology +4

In vivo gene transfer of Kv1.5 normalizes action potential duration and shortens QT interval in mice with long QT phenotype

Michael Brunner, Sodikdjon A. Kodirov, Gary F. Mitchell, +8

American Journal of Physiology-Heart and Circulatory Physiology