Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

Li-Zhen He, Fabien Guidez, Carla Tribioli, +4

Nature Genetics

Molecular PhysiologySignal TransductionMolecular BiologyDistinct InteractionsSystems Biology +2

Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

Li-Zhen He, Thomas Tolentino, Peter C. Grayson, +6

Journal of Clinical Investigation

Histone ModificationsHdac InhibitorsMixed-phenotype Acute LeukemiaEpigeneticsTumor Biology +23

Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

Li-Zhen He, Thomas Tolentino, Peter C. Grayson, +6

Journal of Clinical Investigation

Retinoic acid (RA) and As ₂ O ₃ treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins

Eduardo Magalhães Rego, Li-Zhen He, Raymond P. Warrell, +2

Proceedings of the National Academy of Sciences

Mixed-phenotype Acute LeukemiaImmunologyRetinoic AcidCell DeathTumor Biology +15

M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1

Murugesan V. S. Rajaram, Eusondia Arnett, Abul Azad, +8

Cell Reports

Antigenic Targeting of the Human Mannose Receptor Induces Tumor Immunity

Li-Zhen He, Andrea Crocker, Janine Lee, +10

The Journal of Immunology

Selenium nanoparticles regulates selenoprotein to boost cytokine-induced killer cells-based cancer immunotherapy

Ting Liu, Ligeng Xu, Li-Zhen He, +4

Nano Today

NanomedicineCancer ImmunosurveillanceSelenium DeficiencyMedicineImmunology +6

Antibody-Targeted NY-ESO-1 to Mannose Receptor or DEC-205 In Vitro Elicits Dual Human CD8+ and CD4+ T Cell Responses with Broad Antigen Specificity

Takemasa Tsuji, Junko Matsuzaki, Marcus P. Kelly, +8

The Journal of Immunology

Cancer-testis AgImmunologyImmunoeditingAntigen ProcessingCd4 T Cell Responses +15

Mannose Receptor Targeting of Tumor Antigen pmel17 to Human Dendritic Cells Directs Anti-Melanoma T Cell Responses via Multiple HLA Molecules

Venky Ramakrishna, Laura Vitale, John E. Connolly, +8

The Journal of Immunology

Dc Mannose ReceptorMannose Receptor TargetingImmunologyAntigen ProcessingCd4 T Cell Responses +14

Agonist Anti-Human CD27 Monoclonal Antibody Induces T Cell Activation and Tumor Immunity in Human CD27–Transgenic Mice

Li-Zhen He, Naseem Prostak, Lawrence J. Thomas, +8

The Journal of Immunology

Adaptive Immune SystemT-regulatory CellImmunologyImmunologic MechanismCd4 T Cell Responses +16