Hao Chen

Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations

Hao Chen, Mengzhen Lai, Tao Zhang et al. · Journal of Medicinal Chemistry · 2022 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo

Yingqiang Liu, Mengzhen Lai, Shan Li et al. · Cancer Science · 2021 · 51 citations · Full text

Medicine, Oncology, Pharmacology +14

Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation

Gregory B. Craven, Hang Chu, Jessica D. Sun et al. · Nature · 2024 · 33 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors

Zhen Zhang, Jie Li, Hao Chen et al. · Journal of Medicinal Chemistry · 2022 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network

Jacqueline Weaver, Gregory B. Craven, Linh Tram et al. · Journal of the American Chemical Society · 2024 · 15 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17