Hao Chen

LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo

Yingqiang Liu, Mengzhen Lai, Shan Li et al. · Cancer Science · 2021 · 49 citations · Full text

Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations

Hao Chen, Mengzhen Lai, Tao Zhang et al. · Journal of Medicinal Chemistry · 2022 · 49 citations · Full text

Drug Target, Molecular Biology, Pharmaceutical Chemistry +16

Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation

Gregory B. Craven, Hang Chu, Jessica D. Sun et al. · Nature · 2024 · 22 citations

Drug Targeting, Medicine, Mutant-selective Akt Inhibition +3

Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors

Zhen Zhang, Jie Li, Hao Chen et al. · Journal of Medicinal Chemistry · 2022 · 17 citations · Full text

Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network

Jacqueline Weaver, Gregory B. Craven, Linh Tram et al. · Journal of the American Chemical Society · 2024 · 13 citations