PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Nikolaos Patsoukis, Kankana Bardhan, Pranam Chatterjee, +9

Nature Communications

ImmunologyMetabolic RemodelingFatty Acid OxidationAmino Acid MetabolismT Cells +17

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

Zaheed Husain, Yannu Huang, Pankaj Seth, +1

The Journal of Immunology

Chemoprevention StrategyImmunologyNk CellsImmunotherapyCancer Biology +14

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

Weina Zhang, Guihua Wang, Zhigang Xu, +23

Cell

Signal TransductionSignaling PathwayCell RegulationImmunologyRlr Signaling +7

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

Barbara Wegiel, David Gallo, Eva Csizmadia, +12

Cancer Research

Cell DeathMetabolic ExhaustionMetabolic RemodelingCancer BiologyTumor Biology +14

Modeling precision treatment of breast cancer

Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, +24

Genome biology

Lactate dehydrogenase activity drives hair follicle stem cell activation

Aimee Flores, John C. Schell, Abigail S. Krall, +14

Nature Cell Biology

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen‐activated protein Kinase (MAPK) and Phosphatidylinositol‐3‐kinase (PI3K)/AKT pathways

Jun‐ichi Hanai, Nathaniel C. Doro, Atsuo T. Sasaki, +4

Journal of Cellular Physiology

Cell DeathCancer BiologyTumor BiologySignaling PathwayCell Regulation +19

Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma

Saeed Daneshmandi, Barbara Wegiel, Pankaj Seth

Cancers

HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells

Ian E. Krop, Dennis C. Sgroi, Dale Porter, +12

Proceedings of the National Academy of Sciences

A neural survival factor is a candidate oncogene in breast cancer

Dale Porter, Stanislawa Weremowicz, Koei Chin, +16

Proceedings of the National Academy of Sciences

Serial AnalysisSage TagBreast OncologyGliomaOncogenic Agent +13