Kang Le

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Michael Soth, Kang Le, Maria Emilia Di Francesco et al. · Journal of Medicinal Chemistry · 2020 · 91 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways

Donna Badgwell, Zhimin Lu, Kang Le et al. · Oncogene · 2011 · 85 citations

Medicine, Molecular Biology, Oncology +16

Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments

Jiacheng Ma, Sunil Goodwani, Paul Acton et al. · Pain · 2021 · 32 citations · Full text

Medicine, Neuroscience, Pharmacology +16

Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy

Kang Le, Michael Soth, Jason B. Cross et al. · Journal of Medicinal Chemistry · 2023 · 24 citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Sunil Goodwani, Celia Fernandez, Paul Acton et al. · International Journal of Molecular Sciences · 2020 · 23 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17